Lecture27-1 - Electron transport and ATP synthesis are...

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Electron transport and ATP synthesis are coupled Electron transport and ATP synthesis are coupled by a proton gradient across the inner mitochondrial membrane The proton gradient has two components -A chemical gradient ( ΔpH ) -An electrical gradient ( ΔV ) The flow of protons back known as the “proton motive force” powers ATP synthesis V ZF RT + = + + cyto matrix ] [H ] H [ ln G chemical electrical Chemiosmotic synthesis
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ATP synthase: Composed of two multisubunit components: F o (proton-conducting unit) and F 1 (catalytic subunit) F o : Integral membrane proton channel: -ring of 10-14 “ c-subunits ” which form proton channel - “ a subunit ” binds to outside of ring F 1 : - α3 β3 hexamer binds nucleotides, β subunit synthesizes ATP - β subunits synthesize ATP F o and F 1 are connected by central γε stalk and by an exterior column “ b2 subunit ATP synthase Structure: F 1 and F o
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ATP synthesis: The binding change mechanism The role of proton gradient is not to form ATP but release it from the synthase Paul Boyer proposed a binding change mechanism for proton-driven ATP synthesis
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This note was uploaded on 05/05/2011 for the course BIOL 400 taught by Professor Dr.biology during the Spring '11 term at University of Tennessee.

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Lecture27-1 - Electron transport and ATP synthesis are...

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