3 - Methylation and HIV and Epigenetics HIV is a cytopathic...

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Click to edit Master subtitle style Role of Histone Modification on  Transcriptional Regulation and  HIV-1 Gene Expression: Possible Rachel Dunlap, Alexis  Williams, Hannah Gray, Hank  Walker, and Paolo Vignali
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Epigenetics The study of heritable changes in phenotype  or gene expression caused by mechanisms  other than changes in the underlying DNA  sequence  These changes may remain through cell  divisions for the remainder of the cell’s life and  may last for multiple generations
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Histones Highly alkaline proteins found in eukaryotic  cell nuclei that package and order the DNA  into structural units called nucleosomes They’re the the chief protein components of  chromatin, acting as spools around which  DNA winds, and they play a role in gene  regulation De-methylation H3 and H4 histones promote  silencing of host cellular genes, while in 
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Acetylation and Deacetylation
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Unformatted text preview: Methylation and HIV and Epigenetics HIV is a cytopathic retrovirus and the primary etiological agent of acquired immunodeficiency syndrome (AIDS) and related disorders Histone acetylation can alter conformation of HIV changing it from inactive to active These studies indicate that epigenetic silencing is deeply involved in the maintenance of HIV-1 transcriptional latency, HIV and Periodontal Disease A study found a correlation between p-gingivitis and HIV Gingivitis produces butyric acid, which acts like an enzyme and catalyzes acetylation causing the conformation to change from inactive to active AIDS development is more rapid in individuals with dual infections*** There are no data to indicate whether prevention and treatment of periodontal disease have a similar effect on AIDS progression, but it is...
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This note was uploaded on 05/05/2011 for the course BIOL 400 taught by Professor Dr.biology during the Spring '11 term at University of Tennessee.

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3 - Methylation and HIV and Epigenetics HIV is a cytopathic...

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