31GlycogenSynthesisBreakdownu

31GlycogenSynthesisBreakdownu - Glycogen Metabolism...

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1 Glycogen Metabolism material we’ll cover: Characteristics of Glycogen Particles Why Glycogen? Glycogen Breakdown • 3 steps to breakdown • Conversion to glucose 6-phosphate Glycogen Synthesis • 3 steps to synthesis • diseases Regulation of glycogen metabolism Readings: pages 592-596 pages 598-612 Suggested problems pages 615-616: #2, 3, 7, 9, 10, 11 Metabolic flow of carbon through glucose 6-phosphate Glycogen is present as an insoluble granule in the cytosol of muscle and liver cells Because of multiple non-reducing ends, it is a readily mobilizable source of glucose during times of need ( exercise in muscle , or release of glucose from the liver during fasting) Glycogen: A highly branched polymer of glucose
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Glycogen: A highly branched polymer of glucose Glycogen: A highly branched polymer of glucose Glycogen is a large polymer of glucose (55,000 residues) Linked by α1-4 glycosidic bonds with α1-6 “branch points” located every 8-12 residues The result is a highly branched polymer with many
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31GlycogenSynthesisBreakdownu - Glycogen Metabolism...

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