L03_2002 - Lecture 3: Phosphorylase (parts of Chapter 15 +...

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Unformatted text preview: Lecture 3: Phosphorylase (parts of Chapter 15 + Buchbinder et al . 2001) Discussion of paper and talk assignments. Notes: A PDF of Buchbinder et al . 2001 will be posted on the course web site today. For your professional growth as a scientist (as well as potential extra credit on EXAM 1), you should read this paper. The course materials will be posted on eRES soon, perhaps as early as this Friday. The PASSWORD for this course on eRES will be: biochem2 Review: Glycogen o lysis requires 3 major enzymes: 1) GLYCOGEN PHOSPHORYLASE (bond cleavage by phosphor olysis) Glycogen (n units) + P i <--- Glycogen (n-1) + G-1-P inorganic phosphate Glucose-1-phosphate 2) GLYCOGEN DEBRANCHING ENZYME (Fig. 15-6) 3) PHOSPHOGLUCOMUTASE (Fig. 15-7): G-1-P < --- G-1,6-P < --- G-6-P Glucose-1,6-bis phosphate Glucose-6-phosphate Review: Glycogen SYNTHESIS requires 3 major enzymes, and occurs by a SEPARATE PATHWAY from glycogenolysis: 1) UDP-GLUCOSE PYROPHOSPHORYLASE (Fig. 15-9): G-1-P + UTP < ---...
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L03_2002 - Lecture 3: Phosphorylase (parts of Chapter 15 +...

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