lec30 - Biochemistry I Fall Term, 2004 November 19, 2004...

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1 Biochemistry I Fall Term, 2004 November 19, 2004 Lecture 30: Glycogen Metabolism/Gluconeogenesis Key Terms: Glycogen synthase UDP-glucose Phosphorylation cascade Gluconeogenesis Fructose-2,6-bisphosphate (F2,6P) Substrate cycling Hormonal control: Protein kinase A Phosphorylase kinase Phosphoprotein phosphatase Links : ( I ) Review Quiz on Lecture 30 concepts ( S ) Muscle Glycogen Phosphorylase : Chime page showing the R and T state conformations. Regulation of anabolic (synthesis) and catabolic (degradation) pathways 1. Synthetic and degradative pathways usually use the same enzyme for steps in which G = 0. 2. Synthetic and degradative pathways always utilize different enzymes for steps in which G << 0. 3. Regulatory steps ( G << 0) are often the same in both pathways. 4. Consequently, regulatory enzymes are always different and they can respond to regulatory signals in different ways. 5. Flux through pathways is often controlled by competing rates of synthesis and degradation.
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2 Glycogen Synthesis and Degradation Glycogen synthesis is catalyzed by glycogen synthase. Glycogen degradation is catalyzed by glycogen phosphorylase.
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lec30 - Biochemistry I Fall Term, 2004 November 19, 2004...

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