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Metabolism - Glycogen Metabolism Introduction Storage...

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Glycogen Metabolism Introduction
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Storage Polysaccharides O CH 2 O H O H O O H O CH 2 O H O H HO O H O O CH 2 O H OH O OH O O CH 2 OH OH O CH 2 O H O H O H O O HO CH 2 OH O H O H O H α(1∇ 629 λινκαγε α(1∇ 429 λ ινκαγε
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Why Polysaccharides? Rapid mobilization Support anaerobic metabolism Animals cannot convert fats to  glucose precursors
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Why Polymers? Osmotic Problem!
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Glycogen Metabolism PP i UT P UDP Glycogen  (Gluc os e ) n+1 UDP- Glucose Glucose- 1- P P i Glucose- 6- P 2  P i Glycogen (Gluc o se ) n Glycogen   (Gluc os e ) n Glyc o ge n S ynthase Glyc og e n Ph os ph or ylas e Phos phog luc o mutas e UDP- Gluc os e Pyr oph os ph or ylas e Pyr ophos ph atas e
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Glycogen Breakdown
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Storage Tissues Liver : Glucose for bloodstream Muscle : Glucose for anaerobic ATP synthesis  (Glycolysis)
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Pathway Overview Structure of Glycogen Glycogen Phosphorylase Phosphoglucomutase Glycogen Debranching Enzyme
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Structure of Glycogen α - (1 Ñ >4 )  Linkage s a -(1 Ñ >6 ) Linkag e a -(1 Ñ >4 ) Linkag e s
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Glycogen Phosphorylase [ α (1 —> 4) Linkages] (Gluc o se ) n   +  P i (Gluc o se ) n- 1   +  Gluc os e Ð 1 Ð P
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Phosphoglucomutase Gluc os e Ð 1 Ð P Gluc o s e Ð 6 Ð P
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Glycogen Debranching Enzyme [ α (1 —> 6) Linkages] (Gluc o s e ) n (Gluc os e ) n- 1   +  Gluc os e
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Reactions of Glycogen Breakdown
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Glycogen Phosphorylase At Le ast  5  Unit s
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Reaction of Glycogen Phosphorylase O O CH 2 O H O H HO O H H H O H H O CH 2 O H H O H H H O H H Ð O P O O O Ð H O CH 2 O H H HO O H H H O H H O P O O CH 2 O H H H O O H H H O H H Gluc o s e - 1- P PLP Glyc o g e n (Gluc os e ) n-1 NO T E: Re t e ntio n of  Conf igur at ion
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Mechanism of Glycogen Phosphorylase O CH 2 O H HO HO O H O CH 2 O H HO HO O H O 1, 5- Gluconolact one (inhib itor ) Half - chair oxonium ion (pr opos e d int e rm e diate ) Binding Crevice Accommodates 4-5 Sugar Residues
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Role of Pyridoxal Phosphate (Vitamin B 6 – essential cofactor) N C O H H CH 2 O P HO O O Ð O H
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