Metabolism - Glycogen Metabolism Introduction Storage...

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Unformatted text preview: Glycogen Metabolism Introduction Storage Polysaccharides O CH 2 O H O H O O H O CH 2 O H O H HO O H O O CH 2 O H OH O OH O O CH 2 OH OH O CH 2 OH O H O H O O HO CH 2 OH OH OH OH (1 6 29 (1 4 29 Why Polysaccharides? Rapid mobilization Support anaerobic metabolism Animals cannot convert fats to glucose precursors Why Polymers? Osmotic Problem! Glycogen Metabolism PP i UT P UDP Glycogen (Gluc os e ) n+1 UDP- Glucose Glucose- 1- P P i Glucose- 6- P 2 P i Glycogen (Gluc o se ) n Glycogen (Gluc os e ) n Glyc o ge n S yntha se Glyc og e n Ph os ph or ylas e Phos phog luc o mutas e UDP- Gluc os e Pyr oph os ph or ylas e Pyr ophos ph atas e Glycogen Breakdown Storage Tissues Liver : Glucose for bloodstream Muscle : Glucose for anaerobic ATP synthesis (Glycolysis) Pathway Overview Structure of Glycogen Glycogen Phosphorylase Phosphoglucomutase Glycogen Debranching Enzyme Structure of Glycogen - (1 >4 ) Linkage s a-(1 >6 ) Linkag e a-(1 >4 ) Linkag e s Glycogen Phosphorylase [ (1 > 4) Linkages] (Gluc o se ) n + P i (Gluc o se ) n- 1 + Gluc os e 1P Phosphoglucomutase Gluc os e 1P Gluc o s e 6 P Glycogen Debranching Enzyme [ (1 > 6) Linkages] (Gluc o s e ) n (Gluc os e ) n- 1 + Gluc os e Reactions of Glycogen Breakdown Glycogen Phosphorylase At Le a st 5 Unit s Reaction of Glycogen Phosphorylase O O CH 2 O H O H HO O H H H O H H O CH 2 O H H O H H H O H H O P O O O H O CH 2 O H H HO O H H H O H H O P O O CH 2 O H H H O O H H H O H H Gluc o s e - 1- P PLP Glyc o g e n (Gluc os e ) n-1 NO T E: Re t e ntio n of Conf igur at ion Mechanism of Glycogen Phosphorylase O CH 2 O H HO HO O H O CH 2 O H HO H O O H O 1, 5- Gluconolact one (inhib itor ) Half - chair oxonium ion (pr opos e d int e r m e dia te ) Binding Crevice Accommodates 4-5 Sugar Residues Role of Pyridoxal Phosphate...
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Metabolism - Glycogen Metabolism Introduction Storage...

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