Study Guide for Fatty Acid Metabolism

Study Guide for Fatty Acid Metabolism - Study Guide for...

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Study Guide for Fatty Acid Metabolism I. Fatty Acid Catabolism A. Draw a triglyceride molecule. Explain why it is energetically more favorable to store energy as fats rather than as proteins or carbohydrate. B. What enzyme is necessary to release free fatty acids from triglycerides? Show its reaction. What two hormones regulate this enzyme and why? Show the signal transduction process necessary to regulate this enzyme. C. Acyl Co. A synthetase is necessary to activate the free fatty acid for breakdown. Show the overall reaction catalyzed by this enzyme. D. The ΔG ’o of the acyl Co. A synthetase is close to zero but the reaction is essentially irreversible in the cell. How is this achieved? What enzyme is involved? E. Two high energy phosphate bonds are hydrolyzed to activate fatty acids for breakdown. Using the c oncept of energy coupling, calculate the ΔG ’o for the activation of palmitate. ATP + H 2 O → ADP + P i ΔG ’o = -30.5 kJ/mol ATP + H 2 O → AMP + PP i ΔG ’o = -45.6 kJ/mol Palmitoyl- C o A + H 2 O →Palmitate + Co.A ΔG ’o = -34 kJ/mol PP i + H 2 O→ 2P i ΔG ’o = -19.3 kJ/mol F. Explain how fatty acids are activated and taken up into the mitochondria. What is carnitine? What
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This note was uploaded on 05/05/2011 for the course BIOL 400 taught by Professor Dr.biology during the Spring '11 term at University of Tennessee.

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Study Guide for Fatty Acid Metabolism - Study Guide for...

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