365 S2011 L10 - Chapter 6 ! Three Dimensional Structure of...

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1 Chapter 6 Three Dimensional Structure of Proteins
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2 Primary structure - covalent bonds Secondary structure - noncovalent interactions Tertiary structure - noncovalent interactions Quartenary structure - noncovalent interactions Folding Structure
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3
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4 Formation of the peptide bond Polypeptide backbone
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5 Peptide bond — partial double bond character No rotation
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6 Six atoms of the peptide group lie in a single plane peptide group usually in trans conformation
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7 Steric hindrance between side groups
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8 Peptide backbone: a string of beads How does a polypeptide fold up? Rotation around C α -N and C α -C
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9 Relative orientation of peptide groups is speciFed by the φ and ψ angles φ (phi): rotation around C α -N ψ (psi) rotation around C α -C φ and ψ torsion angles or dihedral angles
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• When both peptide groups are in the same plane and the polypeptide is stretched out , the torsion angles are defned as 180° • Looking From the C α rotating clockwise increases the angle
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365 S2011 L10 - Chapter 6 ! Three Dimensional Structure of...

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