365 S2011 L15 - Quiz 2 ! high 40 (14)! low 5! mean 29! sd...

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1 Quiz 2 high 40 (14) low 5 mean 29 sd 8
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2 2,3-BPG decreases the afFnity for O 2 • Synthesized in red blood cells • Lowers the afFnity for O 2 • In the absence of 2,3 BPG the afFnity for O 2 would be to high • Binds in a 1:1 ratio to Hb
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4 2,3 BPG binds to basic groups on the β chains
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5 2,3 BPG plays a role in altitude adaptation and delivery of O 2 to the fetus At high altitude the pO 2 is lower Increase in 2,3-BPG concentration Small decrease in O 2 -binding (lungs) Much larger increase in O 2 release (tissues)
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7 • O 2 binding at one site increases the afFnity of the other sites for O 2 • H + decreases the afFnity of Hb for O 2 • CO 2 decreases the afFnity of Hb for O 2 • 2,3 DPG decreases the afFnity of Hb for O 2 Allosteric effects Binding of a molecule to one site on a protein affects binding of a second molecule to a different site on the same protein
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8 Chapter 8 Carbohydrates Monosaccharides Oligosaccharides Polysaccharides Glycoproteins
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365 S2011 L15 - Quiz 2 ! high 40 (14)! low 5! mean 29! sd...

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