365 S2011 L20 - 6 Flipase 7 Chapter 10 Membrane transport 8...

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Midterm 2 high 98 low 19 mean 55 sd 17
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2 The inner and outer leafet oF a membrane diFFer in lipid composition Erythrocyte membrane
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3 How is this asymmetry accomplished? Lipids are synthesized at the ER and GA 1. Asymmetric synthesis 2. Transfer between inner and outer leaFets ±lippases Phospholipid translocases - use ATP and can move lipids from a leaFet with a lower concentration to a leaFet with higher concentration
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4 Bacterial lipids are synthesized at the inner leafet oF the plasma membrane and transported to the outer leafet Newly synthesized lipids can be labeled by Feeding the bacteria labeled precursors Lipids in the outside leafet can be labeled with non-membrane permeable reagents – TNBS reacts with phosphatidylethanolamine
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5 1. New lipids are made on the inside 2. They appear on the outside soon after synthesis
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Unformatted text preview: 6 Flipase 7 Chapter 10 Membrane transport 8 Why do we need transport? Import biological molecules (fuel and building blocks) Export of waste Transport of building blocks or degradation products between organelles and the cytoplasm Regulate osmotic pressure Regulate concentration of certain ions Create gradients of ions across membranes 9 Transport 1. Passive- does not require imput of energy 2. Active- requires input of energy 10 Movement of molecules across a membrane resembles a chemical reaction 11 G A = G A (in) G A (out) G A = G A + RT ln A [ ] in-G A + RT ln A [ ] out ( ) G A = RT ln A [ ] in A [ ] out R = gas constant, 8.314 J/K.mol...
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365 S2011 L20 - 6 Flipase 7 Chapter 10 Membrane transport 8...

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