365 S2011 L23 - 4 5 G = free energy of activation G =...

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1 Activation energy and transition state 1. Spontaneous reactions ( Δ G < 0) can occur at a very low rate 2. Δ G° for oxidation of glucose is -686 kcal/mole Thermodynamically glucose is not very stable 3. Glucose does not oxidize at a measurable rate Kinetically stable 4. High energy transition state
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3 1. A reactant needs a certain amount of energy to reach the transition state 2. The reaction rate depends on the number of molecules that reach the transition state per unit of time 3. We can increase the rate in two ways: Increase the temperature Reduce the energy of the transition state
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Unformatted text preview: 4 5 G = free energy of activation G = change in free energy of the reaction Reaction coordinate diagram equilibrium constant k = e- G/RT rate is proportional to e- G /RT 6 Catalysts reduce the G 7 8 EfFciency of a enzyme: The difference between G of catalyzed and uncatalyzed reactions is G cat Rate enhancement : rate cat /rate uncat = e G cat /RT 5.7 kJ/mol 10 fold increase 34 kJ/mol 10 6 fold increase...
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This note was uploaded on 05/07/2011 for the course CHEM 365 taught by Professor Huxford during the Spring '08 term at San Diego State.

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365 S2011 L23 - 4 5 G = free energy of activation G =...

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