365 S2011 L24 - Quiz 3! high 40! low 20! mean 32! sd 4!...

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Quiz 3 high 40 low 20 mean 32 sd 4
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2 EfFciency of a enzyme is related to The difference between Δ G of uncatalyzed and catalyzed reactions ( ΔΔ G cat ) Rate enhancement : rate cat /rate uncat = e ΔΔ G cat /RT 5.7 kJ/mol — 10 fold increase 34 kJ/mol — 10 6 fold increase
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3 Enzymes Decrease Δ G Do not change Δ G ° Increase the rate Do not change equilibrium
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4 1. Acid-base catalysis 2. Covalent catalysis (nucleophilic) 3. Metal ion catalysis 4. (Electrostatic catalysis) 5. Proximity and orientation effects 6. Preferential binding of transition state complex Catalytic mechanisms
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5 Acid-base catalysis 1. General acid catalysis — partial donation of a proton 2. General base catalysis — partial proton extraction 3. Combination — concerted acid-base catalyzed reaction 4. Asp, Glu, His, Lys, Tyr, Cys
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6 Keto-enol tautomerization
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7 How can an enzyme help?
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8 Bovine pancreatic RNase A
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9 RNAse A uses a concerted acid-base catalysis to hydrolysis of a phosphoester bond
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365 S2011 L24 - Quiz 3! high 40! low 20! mean 32! sd 4!...

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