Ch7 - Protons bind to the amino-terminal amino group in the...

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Chem 365 Homework solutions Chapter 7 1-3. From Voet, Voet & Pratt (VVP), Chapter 7: Problems 1, 2, and 5 (pages 216-217). 4. An increase in concentration of carbon dioxide (CO2) lowers the pH in a tissue. In such an environment the O2 binding affinity of hemoglobin decreases . a. raises; increases b. raises; decreases c. lowers; increases d. lowers; decreases 5. On the graph below are depicted the O2 binding curves for myoglobin and hemoglobin at pH 7.4. a. Label the curves Mb (myoglobin) and Hb (hemoglobin). b. Why do the two curves differ? There are interactions (cooperativity) between the subunits in Hb. c. Which of these curves will differ significantly as a function of pH? Draw the new curve at pH 6.8. Hb d. Explain the molecular mechanism of this pH dependence.
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Unformatted text preview: Protons bind to the amino-terminal amino group in the ! chains and a carboxy-terminal histidine side chain in the " chains. When protonated these groups engage in ionic interactions that stabilize the deoxy or T form. Mb Hb Hb at pH 6.8 Chem 365 Homework solutions e. Give the physiological consequences of this pH dependence. The pH in the lung is higher, consequently Hb has a higher affinity for O 2 in the lungs, resulting in more O 2 binding in the lungs. The pH in the tissues is lower, consequently Hb has a lower affinity for O 2 in the tissues, resulting in more release of O 2 in the tissues. More O 2 binding in the lungs and more O 2 release in the tissues equals more transport....
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Ch7 - Protons bind to the amino-terminal amino group in the...

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