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Unformatted text preview: Protons bind to the amino-terminal amino group in the ! chains and a carboxy-terminal histidine side chain in the " chains. When protonated these groups engage in ionic interactions that stabilize the deoxy or T form. Mb Hb Hb at pH 6.8 Chem 365 Homework solutions e. Give the physiological consequences of this pH dependence. The pH in the lung is higher, consequently Hb has a higher affinity for O 2 in the lungs, resulting in more O 2 binding in the lungs. The pH in the tissues is lower, consequently Hb has a lower affinity for O 2 in the tissues, resulting in more release of O 2 in the tissues. More O 2 binding in the lungs and more O 2 release in the tissues equals more transport....
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- Spring '08
- pH, Hemoglobin, O2 binding curves, O2 binding affinity