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L5 - → 3’ AUCG 13 Watson and Crick(1953 • Rosalind...

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2 1. Act as extracellular messengers 2. Carry energy (phosphoanhydride bonds) 3. Reducing power (electrons) 4. Building blocks for DNA 5. Building blocks for RNA Nucleotide function
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3
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4 Adenosine acts as an autocoid Regulates a variety of processes Vessel dilation, smooth muscle contraction, hart rate, sleep During wakefulness adenosine levels in the brain rise causing sleepiness
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5 Adenine nucleotides and metabolism
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6 ATP acts as a carrier of energy
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7 Flavin adenine dinucleotide (FAD) Riboflavin is Vit B 2
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8 Nicotinamide adenine dinucleotide (NAD + )
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9 ATP carries energy FADH 2 and NADH carry electrons to the electron-transport chain NADPH carries electrons to sites of biosynthesis Adenine nucleotides and metabolism
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10 Nucleic Acid Structure Nucleic acids are polymers of nucleotides DNA is a polymer of deoxynucleotides RNA is a polymer of ribonucleotides
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11 Nucleotides are linked by 3’-5’ phosphodiester bonds
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12 Sequences are written 5’
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Unformatted text preview: → 3’ AUCG 13 Watson and Crick (1953) • Rosalind Franklin ʼ s X-Ray diffraction data • Chargaff ʼ s rules • Jerry Donoghue knowledge of the correct tautomeric forms of the bases • Reliable mechanism for replication 14 Rosalind Franklin ʼ s data: DNA is a helix 15 Chargaff ʼ s rule A = T G = C Rule applies to DNA not RNA 16 Tautomeric forms of the bases 17 Predominant tautomeric forms 18 Base-pairing - H-bonding between the bases Interfaces are complementary 19 Watson and Crick 20 Two anti-parallel strands held together by H-bonds between the bases 21 DNA forms a right-handed helix 22 Characteristics of DNA 1. Double helix 2. Stands run anti-parallel 3. Bases are planar and are in the center of the helix 4. Major and a minor groove 5. Bases on one strand base-pair with complimentary bases on the other strand 6. Sugar is deoxyribose 23 DNA can be replicated reliably...
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