Lecture 2 Outline - Deletion ( Fig. 9.4, 9.9) Chromosome...

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Bio 352 1 of 4 LECTURE 2 : Mutations Definition Somatic vs. germ-line mutations (Fig. 10.1 ) Monomorphic genes Polymorphic genes “Wild type” vs. “mutant” alleles Forward vs. reverse mutations Gene (“point”) Mutations (Fig. 10.2) Base substitutions (Fig. 10.3, 10.6) Transitions Transversions Missense mutations Nonsense mutations
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Bio 352 2 of 4 Silent mutations Examples: Sickle-cell hemoglobin Cystic fibrosis Base Insertion Base Deletion Insertions and deletions result in frame shifts Chromosome mutations Duplications ( Fig. 9.4a, 9.5 ) Tandem duplication Displaced duplication Reverse duplication
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Unformatted text preview: Deletion ( Fig. 9.4, 9.9) Chromosome inversion ( Fig. 9.4c, 9.11, 9.12) Bio 352 3 of 4 Chromosome translocations ( Fig. 9.4d) Reciprocal translocations Non-reciprocal translocations Robertsonian translocations ( Fig. 9.15, 9.17) Changes in Chromosome Number Aneuploidy ( Fig. 9.21, 9.22, 9.24) Monosomy Trisomy Polyploidy u Autopolyploidy ( Fig. 9.26) Allopolyploidy ( Fig. 9.27) Bio 352 4 of 4 Spontaneous mutations Induces mutations and mutagens Mutation rates Next Time : Mendel, Monohybrid Cross, Probability Theory (Lecture 3) Readings : Pierce, pgs. 43 - 54...
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This note was uploaded on 05/07/2011 for the course BIOLOGY 352 taught by Professor Townsend during the Spring '08 term at San Diego State.

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Lecture 2 Outline - Deletion ( Fig. 9.4, 9.9) Chromosome...

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