Lecture 2 Questions

Lecture 2 Questions - Lecture 2: Study Questions 1. What is...

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Lecture 2 : Study Questions 1. What is the difference between somatic mutations and germ-line mutations? 2. What is the difference between a transition and a transversion? Which type of base substitution is usually more common? 3. What is the difference between a missense mutation and a nonsense mutation? A silent mutation and a neutral mutation? 4. A codon that specifies the amino acid Gly undergoes a single-base substitution to become a nonsense mutation. In accord with the genetic code given in Figure 15.10 (Pierce Extra), is this mutation a transition or a transversion? At which position of the codon does the mutation occur? 5. If a single transition occurs in a codon that specifies Leu, what amino acids could be specified by the mutated sequence? 6. Hemoglobin is a complex protein that contains four polypeptide chains. The normal hemoglobin found in adults—called adult hemoglobin—consists of two α and two β polypeptide chains, which are encoded by different loci. Sickle-cell hemoglobin, which causes sickle-cell anemia, arises from a mutation in the β chain of adult hemoglobin. Adult hemoglobin and sickle-cell hemoglobin differ in a single amino acid: the sixth amino acid from one end in adult hemoglobin is glutamic acid, whereas sickle-cell hemoglobin has valine at this position. After consulting the genetic code provided in Figure 15.10, indicate the type and location of the mutation that gave rise to sickle-cell anemia. 7. The following nucleotide sequence is found on the template strand of DNA. First, determine
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Lecture 2 Questions - Lecture 2: Study Questions 1. What is...

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