13_352 - Lecture 13 Mutation and migration T o d a y s t o...

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Lecture 13: Mutation and migration Today s topics: 1. Mutation (general) 2. Forward mutation model 3. Forward-backward mutation model 4. Mutation vs. migration 5. Migration (gene flow) One-way migration Island migration model Readings: Readings: Pierce Pierce 344-346 344-346 Review: Mutations occur at low rates Mutation Rate (mutations/gamete/gen) Hemophilia A 3 X 10 -5 Muscular dystrophy 8 X 10 -5 Retinitis pigmentosa 1 X 10 -6 Mutation
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Because mutations are a negligible force on a generation-to-generation basis… they are usually not an important microevolutionary force … but they are the ultimate source of all new genetic variation. Mutation Forward Mutation Model 1. Alleles A and a present in initial frequencies of p 0 and q 0 . 2. A mutates to a at rate μ . 3. p 1 = p 0 - p 0 μ = p 0 (1 - μ ) p 2 = p 1 (1 - μ ) = p 0 (1 - μ )(1 - μ ) = p 0 (1 - μ ) 2 p t = p 0 (1 - μ ) t t = # generations 4. Also, Δ q = μ p equation 23.11 A a µ
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Example: Q : A gene with a high mutation rate has μ = 1 x 10 -5 . If p = 1.0, what will the gene pool
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This note was uploaded on 05/07/2011 for the course BIOLOGY 352 taught by Professor Townsend during the Spring '08 term at San Diego State.

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13_352 - Lecture 13 Mutation and migration T o d a y s t o...

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