11SNTR342LipidMet2 - Lipid Metabolism 2 Reading: Gropper...

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Lipid Metabolism 2 Reading: Gropper 4 th ed, Ch 6, pp. 153–162 Gropper 5 th ed, Ch 5 pp. 159–168
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2 Objectives for today: Synthesis of fatty acids Synthesis of eicosanoids Metabolism of cholesterol
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3
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4 Fatty acid synthesis Except for linoleic acid and α -linolenic acid (and derivatives), body can make fatty acids from acetyl CoA Two important reactions to remember: 1. Acetyl CoA carboxylase reaction Rate-limiting step Makes “starter” molecule 2. Fatty acid synthase system Elongates chain by 2 carbons 4-step process (repeated)
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5 Fatty acid synthesis Synthesized from acetyl CoA in the cytosol but almost all acetyl CoA is made in the mitochondrial matrix (by various pathways) Acetyl CoA cannot pass through inner mitochondrial membrane In the mitochondrion acetyl CoA is incorporated into citrate (Krebs cycle), which can move to cytosol In the cytosol citrate is converted into oxaloacetate and acetyl CoA (requires ATP)
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6 Fig. 4-15, p. 91
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7 Fig. 6-28a, p. 155
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8 Fatty acid synthesis (cont.) Acetyl CoA carboxylase Adds CO 2 to acetyl CoA to make malonyl CoA Complex enzyme; contains biotin Requires ATP Irreversible; commits acetyl CoA to fatty acid synthesis Rate-limiting step of fatty acid synthesis Inhibited by palmitoyl CoA (16:0 fatty acid-CoA) Activated by citrate
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9 Fig. 6-28b, p. 155
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10 Fatty acid synthesis (cont.) Fatty acid synthase system Multi-enzyme complex Four-step process (repeated) Chain is elongated in 2-carbon (acetate) units Uses acetyl CoA and NADPH NADPH from hexosemonophosphate shunt Process continues until palmitate (C16:0)
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11 Fatty acid synthesis (cont.) Fatty acid synthase system components Acyl carrier protein (ACP) Condensing enzyme (CE)
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This note was uploaded on 05/10/2011 for the course NTR 342 taught by Professor Tillman during the Spring '09 term at University of Texas at Austin.

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11SNTR342LipidMet2 - Lipid Metabolism 2 Reading: Gropper...

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