Micro Lecture 9

Micro Lecture 9 - Microbiology 31 Lecture 9 Microbial...

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Microbiology 31 Lecture 9 Microbial Diseases of the Skin, Eyes, Nervous, Cardiovascular and Lymphatic Systems 1. Integumentary System Barrier against bacterial infections Outer integument secretes sebum and sweat May be anti-microbial May enhance growth of some microorganisms Inner integument secretes mucus Skin contains normal microbiota Dominated by GPC (Gram+ Cocci) Resistant to high salt concentration and desiccation Staphylococcus is one Bacterial diseases of the Skin S. aureus Produces coagulase Many produce a variety of toxins Many produce penicillinase Enzyme that breaks down penicillin and renders it ineffective Agent of many types of skin infections Pimples, sties, impetigo (pustules) May result in toxemia Scalded skin syndrome Toxic Shock syndrome Normally resides on skin Can enter through break in the skin and cause problems S. epidermidis Common component of normal microbiota Often cause of stitch abscesses Most common isolated microorganism of wounds S. pyogenes Group A β–hemolytic streptococcus Produces many toxins Causes erysipelas (red patches) and impetigo May become invasive and cause rapid tissue destruction P. aeruginosa
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Produces several toxins May cause dermatitis, ear infections and burn infections Often difficult to treat due to antibiotic resistance Inflammatory Acne Caused by Propionibacterium acnes Metabolizes sebum trapped in hair follicles Neonatal gonorrhea Caused by N. gonorrhaie Transmitted from the infected mother to the baby during childbirth Viral Diseases of the Skin Warts Papillomaviruses cause benign growth Spread by direct contact Smallpox Caused by variola virus Transmitted by the respiratory system Moved to the skin by the circulatory system High mortality rate There is a vaccine Stored in military and government labs Possible to use for germ warfare (ideal organism) Chickenpox Caused by varicella-zoster virus Transmitted by respiratory system Becomes localized in the skin cells May remain latent, later causing shingles (rash along the cutaneous sensory nerves) Cold Sores Caused by herpes simplex virus May remain latent and reactivate under stress or other factors May manifest into encephalitis
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Measles Caused by Rubeola virus
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Micro Lecture 9 - Microbiology 31 Lecture 9 Microbial...

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