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Unformatted text preview: C. difficile on blood agar Unkown Culturej (German site) Causative agent: Clostridium difficile Category: Bacteria Kingdom: Bacteria Division: Firmicutes Class: Clostridia Order: Clostridiales Family: Clostridiaceae Genus: Clostridium Species: difficile Disease: Pseudomembraneous colitis and antibiotic associated diarrhea. Most common hospital infections in the world, affecting ~20% of patients taking antibiotics. C. difficile-associated disease occurs when the normal intestinal flora is altered, allowing C. difficile to flourish in the intestinal tract and produce a toxin that causes a watery diarrhea. Repeated enemas, prolonged nasogastric tube insertion and gastrointestinal tract surgery increase a person's risk of developing the disease. The overuse of antibiotics, especially penicillin (ampicillin), clindamycin and cephalosporins may also alter the normal intestinal flora and increase the risk of developing C. difficile diarrhea. C. difficile infections are also commonly associated with diarrhea in cancer patients and can complicate the course of ulcerative colitis or Crohn’s disease. This organism is also responsible for 4-12% of diarrhea in AIDS patients.This organism is also responsible for 4-12% of diarrhea in AIDS patients....
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