Electron Microscopy Graphic Representation of single virion Causative agent: Hepatitis C virus (HCV) Category: Virus Classification: This is a description of an vertebrate virus at the genus level. ICTVdB Virus Code: 00.026.0.03. Virus accession number: 026003GE. Former Virus Code: 26.0.3.; former accession number: 26030000. NCBI TaxID: . Name, Synonyms and Lineage: Virus is assigned to the family 00.026 . Flaviviridae . Disease: HCV causes liver disease and is often coexistant with HIV/AIDS because it is mainly passed by intravenous druf users when sharing diryt needles. Number of new infections per year has declined from an average of 240,000 in the 1980s to about 30,000 in 2003.Most infections are due to illegal injection drug use.Transfusion-associated cases occurred prior to blood donor screening; now occurs in less than one per 2 million transfused units of blood.Estimated 3.9 million (1.8%) Americans have been infected with HCV, of whom 2.7 million are chronically infected. The risk for perinatal HCV transmission is about 4%. If coinfected with HIV the risk for perinatal infection is about 19%. Occurs when blood from an infected person enters the body of a person who is not infected. Virions have a complex construction and consist of an envelope and a nucleocapsid. Virions are enveloped by a detergent sensitive lipoprotein. Virions are spherical and estimated to be 50 nm in diameter. Capsid/nucleocapsid is round and exhibits polyhedral symmetry. The core is isometric and has a diameter of about 30 nm. Physicochemical and Physical Properties Virions have a buoyant density in sucrose of 1.09-1.11 g cm-3. The sedimentation coefficient is greater than or equal to 150 S20w. Under in vitro conditions
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This note was uploaded on 05/11/2011 for the course BIO 31 taught by Professor Silva during the Spring '11 term at Reedley.