Lecture+10a

Lecture+10a - Affect on 5-HT system : loss of terminals;...

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1 Neuronal Changes with Amphetamine Use Immediate/acute : increases in extracellular monoamines Long-term : TH, DA content, DA metabolites, DATs GFAP immunoreactivity (marker for gliosis – a glial response to trauma) Affect on DA system : loss of terminals and probably axons; spares cells • greatest effect in Nigrostriatal path • lesser effect in Mesolimbic and Mesocortical paths • Hypothalamic path completely spared
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Unformatted text preview: Affect on 5-HT system : loss of terminals; spares cells terminal loss in: Cortex, Striatum & Hippocampus Dopaminergic Changes with Meth Use 2 Neuronal Degeneration and Trauma Serotonergic Changes with Meth Use 3 Mechanisms of Amphetamine Neurotoxicity Mechanisms of Amphetamine Neurotoxicity (Contd) MS Quinton & BK Yamamoto, 2006 4 Other Long-term Effects of Amphetamines...
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Lecture+10a - Affect on 5-HT system : loss of terminals;...

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