Lecture+11

Lecture+11 - Peaks at ~ 4 days Subsides within 1-3 weeks 3...

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1 Structure of Phenethylamine Hallucinogens, Ecstasy , Amphetamines and Chatecholamines Collage of Ecstasy Pills
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2 Pharmacology of Ecstasy Mechanisms of Action: at monoaminergic synapses (preference for 5-HT system) 1. Binds presynaptic transporter and exchanger 2. Agonist at post-synaptic 5-HT 2 receptors (mild affinity) 3. Inhibits MAO 4. Enhances 5-HT release from presynaptic terminal 5. Inhibits Tryptophan Hydroxylase Acute Effects of Ecstasy Stimulant Energizing Temp motor activity – bruxism Behavioral/Psychological Euphoria Reduced inhibitions and anxiety Emotional openness and empathy (enactogen) Other Reduces secretion of antidiuretic hormone (ADH) retain water Induces production of oxytocin Withdrawal No significant set of symptoms like with opiates Mood worsens – “Mid-week Blues”
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Unformatted text preview: Peaks at ~ 4 days Subsides within 1-3 weeks 3 Neuronal changes with Ecstasy Long Lasting Effects: Depletion of 5-HT and metabolites (5-HIAA) Decrease in SERTs & 5-HT 2 receptors Loss of fine axons from Raphe Nuclei region specific: Striatum, Hippocampus, Prefrontal Cortex Neurotoxicity in DA vs 5-HT systems: Also causes excess DA release from terminals Neuronal changes are species specific rats & primates: 5-HT fiber loss mice: DA fiber loss SERT Density with Ecstasy 4 5-HT2 Receptor Density with Ecstasy Retracted Science Paper (2002) DA toxicity from average dose of ecstasy 5 Retracted Science Paper (2002) DA toxicity from average dose of ecstasy MDMA-induced Loss of Cortical 5-HT Fibers Frontal Cortex Parietal Cortex Visual Cortex 2 weeks 7 years 6 Mescaline...
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Lecture+11 - Peaks at ~ 4 days Subsides within 1-3 weeks 3...

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