310-8 - Organic Lecture Series CH 310 N LECTURE 8 Textbook...

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Organic Lecture Series 1 CH 310 N LECTURE 8 Textbook Assignment: Chap 15 Begin Homework (for credit): POW 2 posted (Due Feb 8) Today’s Topics: Intro to organometallic reagents Notice & Announcements: “Emergency/Trauma Medicine” today, 2-3 WEL 1.308 Carlos Brown, M.D. John P. Sabra, M.D. John M. Uecker, M.D. Organic Lecture Series 2 Organometallic Organometallic Compounds Compounds (Chapter 15) (Chapter 15)
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Organic Lecture Series 3 • Organometallic Organometallic compound: compound: a compound that contains a carbon-metal bond • The focus will be on organometallic compounds of Mg, Li, and Cu – these classes illustrate the usefulness of organometallics in modern synthetic organic chemistry – the use of organometallics can bring about transformations that cannot be accomplished in any other way Organometallic Organometallic compound compound Organic Lecture Series 4 Organometallic reagents have 2 general types of reactions: 1. As Strong bases (Bronsted-Lowry) 2. As nucleophilic reagents. Regard the alkyl group as “R -
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Organic Lecture Series 5 Grignard Reagents Grignard Reagents • Grignard reagent: Grignard reagent: an organomagnesium compound – prepared by addition of an alkyl, aryl, or alkenyl (vinylic) halide to Mg metal in diethyl ether or THF Organic Lecture Series 6 Mg + 1-Bromobutane Butylmagnesium bromide (an alkyl Grignard reagent) ether Br MgBr + ether Mg Br MgBr Bromobenzene Phenylmagnesium bromide (an aryl Grignard reagent) Preparation of Grignard reagents:
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This note was uploaded on 05/16/2011 for the course CH 310 N taught by Professor Blocknack during the Spring '08 term at University of Texas at Austin.

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310-8 - Organic Lecture Series CH 310 N LECTURE 8 Textbook...

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