310-42 - Organic Lecture Series CH 310 N LECTURE 42...

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Organic Lecture Series 1 CH 310 N LECTURE 42 Textbook Assignment: Chapter 26- Lipids Homework (for credit): POW 13 (Due 5/2) Today’s Topics: Steroids & statins Notice & Announcements: Course Survey Organic Lecture Series 2
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Organic Lecture Series 3 Steroids Steroids Steroids: Steroids: a group of plant and animal lipids that have this tetracyclic ring structure: • The features common to the ring system of most naturally occurring steroids are: AB CD Organic Lecture Series 4 Steroids Steroids – the fusion of rings is trans and each atom or group at a ring junction is axial – the pattern of atoms or groups along the ring junctions is nearly always trans -anti- trans - anti- trans H CH 3 H H CH 3 H
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Organic Lecture Series 5 Steroids Steroids –the steroid system is nearly flat and quite rigid –most have have axial methyl groups at C-10 and C-13 Organic Lecture Series 6 glucocorticoid hormones (e.g., cortisone) mineralocorticoid hormones (e.g., aldosterone) sex hormones (e.g., testosterone and estrone) bile acids (e.g., cholic acid) cholesterol Cholesterol is the Cholesterol is the Precursor for Families of Precursor for Families of Steroids Steroids
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Organic Lecture Series 7 Androgens Androgens Androgens - male sex hormones – synthesized in the testes – responsible for the development of male secondary sex characteristics Androsterone Testosterone O H OH H H 3 CH H H 3 3 C H H H 3 C H O HO Organic Lecture Series Synthetic Anabolic Steroids Synthetic Anabolic Steroids
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310-42 - Organic Lecture Series CH 310 N LECTURE 42...

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