8408105-Nephrotic-Nephritic-Syndroms - NEPHROTIC and...

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www.brain101.info 1 NEPHROTIC and NEPHRITIC SYNDROMES Disease Most Frequent Clinical Presentation Pathogenesis Light Microscope F.M. (Fluorescence Microscope) E.M. (Electron Microscope) Age Group Affected Treatment and Outcome Minimal Change Disease (Lipoid Nephrosis) Selective proteinuria (Albumin) Loss of foot processes Loss of GBM polyanionic sites Appearance of villi on epithelial cells Normal Lipid in tubules F.M. = negative E.M. = loss of foot processes, lipid vacuoles #1 cause of Nephrotic Syndrome in children, esp. boys younger than 6 yrs. old. Responds well to corticosteroids. No progression into chronic renal failure Focal Segmental Glomerular Sclerosis Non-selective proteinuria Hypertension Microscopic hematuria Idiopathic Lower renal mass (in obese) 2 causes: heroin use, HIV Focal and segmental sclerosis Hyalinosis Adhesions to Bowman's Capsule Hypercellular mesangium Thick B.M. F.M. = IgM, C3 E.M. = Loss of foot processes, detachment of epithelium from B.M. Majority occur in older children. Also occurs in adults. Does not respond to corticosteroids. Leads to renal failure. Membranous Nephropathy (Glomerulonephritis) Persistent proteinuria Idiopathic 2 causes: carcinomas, SLE, hepatitis, Diabetes Mellitus, thyroiditis, drugs. Glomeruli are
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This note was uploaded on 05/16/2011 for the course NURSING 112 taught by Professor Brinley during the Spring '11 term at Pace.

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8408105-Nephrotic-Nephritic-Syndroms - NEPHROTIC and...

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