{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}


28786616-Anti-Thyroid-Drugs - Just A REVIEW on the thyroid...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Just A REVIEW on the thyroid y Located at the base of the throat, inferior of the Adam s apple Large gla , i-l e ,c ecte y a ce tral ist us 2 hormones secreted y Iodide containing hormones y T3 triiodothyronine y T4 thyroxine y Calcitonin y How do yo control it? Synthesis of thyroid hormones Food Thyroid follicle tyrosine MIT, DIT Iodine s pplements 2 DIT = T4 MIT + DIT = T3 Synthesis of thyroid hormones I Food Thyroid deiodinase Thyroid follicle tyrosine thyroglob lin MIT, DIT Iodine s pplements 2 DIT = T4 MIT + DIT = T3 y The hypothalam s and anterior pit itary y Control the secretion of thyroid hormones thro gh two negative feedback loops Hypothalam s Anterior pit itary TSH Thyroid T3 T4 Effects of Thyroid Hormone y For normal growth and development of the nervo s, skeletal, and reprod ctive systems y Controls the metabolism of fats, carbohydrates, proteins and vitamins Clinical Use: Hypothyroid States y Hormone therapy with either T3 or T4 y Synthetic levothyroxine (T4) is the form of choice in most cases y Triiodothyronine (T3) is faster acting b t has a shorter halflife and more expensive y Levothyroxine, Liothyronine, Liotrix y THYROTOXICOSIS y Warm, moist skin y Sweating, heat intolerance y Tachycardia y Increased appetite y Nervo sness y Decreased fertility y Nervo sness y exopthalmos y HYPOTHYROIDISM y Pale, cool skin y Cold sensation y Bradycardia y Red ced appetite y Lethargy y Weight gain Anti-Thyroid Drugs y Thioamides y Propylthio racil, Methimazole y MOA: block iodination of tyrosine resid es of thyroglob lin and blockade of co pling of DIT and MIT y Synthesis of thyroid hormone is inhibited rather than release y ORAL y Usef l in patients with ncomplicated hyperthyroidism Contraindications: y Methimazole is containdicated in pregnant and n rsing women, PTU maybe given Toxicity: y Skin rash (common), imm ne eactions y Reversible effects y Iodine salts and Iodine y L gol s sol tion (iodine and potassi m iodide), sat rated sol tion of potassi m iodide y MOA: inhibition of iodination of tyrosine in thyroid gland and thyroid hormone release y Decreases the size and vasc larity of the hyperplastic thyroid gland y Faster onset of action y Use: y Thyroid storm, severe thyrotoxicosis, preparation of patients for s rgical resection of the thyroid y Radioactive Iodine y 131I radioactive isotope y MOA: destr ction of the thyroid follicle y Allows permanent c re of thyrotoxicosis y CI: pregnant and n rsing women Hashimoto s Thyroiditis y An a toimm ne disorder which impairs the thyroid's ability to prod ce hormones y Pit itary gland attempts to stim late the thyroid gland to prod ce more thyroid hormones, ca sing yo r thyroid gland to enlarge Graves' disease y a toimm ne disorder, is the most common ca se of an overactive thyroid y antibodies prod ced by yo r imm ne system stim late the thyroid to prod ce too m ch thyroxine Corticosteroids y steroid hormones that are prod ced in the adrenal cortex. y Corticosteroids are involved in a wide range of physiologic systems s ch as y stress response y imm ne response y reg lation of inflammation y carbohydrate metabolism y protein catabolism y blood electrolyte levels y behavior y Glucocorticoids s ch as cortisol control carbohydrate, fat and protein metabolism and are anti-inflammatory by preventing phospholipid release, decreasing eosinophil action and a n mber of other mechanisms y Mineralocorticoids s ch as aldosterone control electrolyte and water levels, mainly by promoting sodi m retention in the kidney Biosynthesis Classes of corticosteroids y Group A y (short to medi m acting gl cocorticoids) y Hydrocortisone y Hydrocortisone acetate y Cortisone acetate y Tixocortolpivalate y Prednisolone y Methyprednisolone y Prednisone y Group B y Triamcinoloneacetonide y Triamcinolone alcohol y Mometasone y Amcinonide y B desonide y Desonide y Fl ocinonide y Fl ocinoloneacetonide y Halcinonide y Group C y Betamethasone y Betamethasone sodi m phosphate y Dexamethasone y Dexamethasone sodi m phosphate y Fl ocortolone y Group D y Hydrocortisone-17-b tyrate y Hydrocortisone-17-valerate y Aclometasonedipropionate y Betamethasonevalerate y Betamethasonedipropionate y Prednicarbate y Clobetasone-17-b tyrate y Clobetasol-17-propionate y Fl ocortolonecaproate y Fl ocortolonepivalate y Fl prednidene acetate Therapeutic outcomes y Gl cocorticoids y Red ced pain and inflammation y Minimized shock syndrome and faster recovery y Red ced na sea and vomiting associated with chemotherapy Types of Corticosteroids y Topical steroidfor se topically on the skin, eye, and m co s membranes. y Inhaled steroids for se to treat the nasal m cosa, sin ses, bronchii, and l ngs y Oral forms - s ch as prednisone and prednisolone. y Systemic forms - available in injectibles for se intraveno sly and parenteral ro tes MINERALOCORTICOIDS y Fl drocortisone y Is an adrenal corticosteroid with potent mineralocorticoid and gl cocorticoid effects. y Affects fl id and electrolyte balance by acting on the distal renal t b les y Used in combination with gl cocorticoids to replace mineralocorticoids activity in patients who s ffer from adrenocortical ins fficiency and to treat salt-losing adrenogenetal syndrome. I am not on STEROIDS Yo are THE ANIMAL!!!!! Thank yo very M ch!!!! ...
View Full Document

{[ snackBarMessage ]}