DNArepair.1

DNArepair.1 - Types of DNA Damage DNA Damage Repair Trun...

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1 DNA Damage Repair 1 Types of DNA Damage Trun Fig 4.1 2 Causes: (1) UV Radiation (2) & (4) Ionizing Radiation (3) Replication Errors, Tautomers, Chemical Mutagens, Recombination (5) Depurination/Depyrimidation I. Pre-Replication Repair 3 A. Base Excision Repair (Part 1) pecific glycosylase • Specific glycosylase detects and removes abnormal base (uracil, xanthine and hypoxanthine) along with the attached 4 ribose • Leaves AP site Griffiths Fig 16-29
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2 Base Excision Repair (Part 2) • AP endonuclease cuts phosphate backbone • The 5’-3’exonuclease activity of DNA Pol I and/or other exonucleases remove downstream ucleotides 5 nucleotides • DNA Pol I and ligase fill in and seal gap Griffiths Fig 16-30 B. Nucleotide Excision Repair (NER) Detects and removes damaged bases resulting from photodimer formation or the addition of bulky products and covalent interstrand crosslinks. Mechanism: 1. UvrA 2 -UvrB complex scans DNA molecules for damage 2. If damage is detected, UvrC replaces UvrA 3. UvrB and C make nicks upstream and downstream of
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This note was uploaded on 05/17/2011 for the course MCDB 101A taught by Professor Thrower during the Spring '08 term at UCSB.

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DNArepair.1 - Types of DNA Damage DNA Damage Repair Trun...

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