Lambdaphage.2

Lambdaphage.2 - Definitions Prophage/lysogen-A phage that has inserted itself into the bacterial chromosome Lysogenic cycle-the process of

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1 Bacteriophage Lambda λ 1 Definitions Prophage/lysogen- A phage that has inserted itself into the bacterial chromosome Lysogenic cycle- the process of insertion and excision of a bacteriophage into its host genome. Virulent phage -A phage that has only a lytic cycle e.g. T4 emperate phage- phage that has both 2 Temperate phage A phage that has both lytic and lysogenic stages, e.g. Lambda Immunity- a cell containing a lysogenic phage cannot be “superinfected” with additional phage of the same type. The Lambda Genome Can be Either Linear or Circular 3 Fig 7.2 4 Fig 19.20
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2 Early and Late Gene Expression 1. “Early” mRNA is transcribed from P L and P R to make N and Cro proteins, respectively. . Normally transcription would stop here but if N 2. Normally transcription would stop here but if N protein reaches a sufficient concentration it prevents termination of the two mRNAs. 3. The extended transcription allows CIII and CII proteins to be made, along with proteins required for phage replication, and another antiterminator “Q”, 5 pg p , Q , which allows transcription of phage structural proteins.
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This note was uploaded on 05/17/2011 for the course MCDB 101A taught by Professor Thrower during the Spring '08 term at UCSB.

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Lambdaphage.2 - Definitions Prophage/lysogen-A phage that has inserted itself into the bacterial chromosome Lysogenic cycle-the process of

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