Review_Session2_Part2

Review_Session2_Part2 - Types TypesofMutations...

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pes of Mutations Types of Mutations icrolesions 1 p utations Microlesions: 1 bp mutations Insertions/Deletions Frameshift mutations b t i tt i Substitutions Transitions: purine purine or yrimidine yrimidine pyrimidine pyrimidine Transversions: purine pyrimidine or yrimidine urine pyrimidine purine
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pes of Mutations Types of Mutations acrolesions 1 p ange Macrolesions >1 bp change Insertions eletions Deletions Duplications i Inversions Translocations
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pes of Mutations Types of Mutations eversions: a second mutation that restores Reversions: a second mutation that restores wildtype phenotype ue reversion: mutation restores original True reversion: mutation restores original genotype seudoreversion mutation restores ildtype Pseudoreversion: mutation restores wildtype phenotype (may only be partial), but may be different genotype a different genotype Suppressor mutations
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pes of Mutations Types of Mutations tragenic ppressors: insertion followed by Intragenic suppressors: insertion followed by compensating downstream deletion tragenic ppressors Extragenic suppressors Nonsense: mutant tRNA inserts AA at stop codon Missense: mutant tRNA which inserts correct AA at mutant codon h i f t tt NA t d 4 d Frameshift: mutant tRNA that reads a 4 bpcodon
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utomeric rms of Bases Tautomeric Forms of Bases ormal form in DNA Normal form in DNA
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Review_Session2_Part2 - Types TypesofMutations...

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