Chapter_6-08 - Chapter 6 Cell Organization Systems Biology...

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1 1 Chapter 6 – Cell Organization: Systems Biology square6 Researchers study living organisms in terms of their underlying network structure rather than their individual molecular components square6 The goal is to understand how the organization of the cell arises by complex interactions between its various components and parts 2 All modern cells come from preexisting cell by division square6 All cells posses a genome square6 Living cells require pre-existing molecules square6 Cells require pre-existing organization
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2 3 Cell’s genetic information produces proteome square6 Information in most genes is used to make mRNA molecules that encode amino acid sequences of proteins square6 Study of individual proteins does not provide a broad integrated look at the dynamic nature of the cell 4 Genomes, proteomes and cell structure function and organization square6 The proteome is largely responsible for the structure and function of living cells square6 Gene and protein regulation causes the proteome to be dynamic square6 Proteins have sorting signals
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3 5 6 square6 Proteins often undergo protein-protein interactions square6 Cells must continually synthesize new molecules and break down unwanted components
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4 7 8 Molecular machines square6 A machine is an object that has moving parts and does useful work square6 These machines provide structure and organization to cells and enable them to carry out complicated processes square6 ATP synthase is a molecular machine that makes ATP box2 Molecular recognition allows for complex assembly square6 Subunits recognize each other and bind in a specific way
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5 9 10 Other molecular machines
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6 11 Cytoskeleton square6 Key role in cell organization and many processes that maintain the cell square6 Provides mechanical strength, cell shape, organization and direction to intracellular and cellular movements 12
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