15. Fertilization 2010 H Hamlin

15. Fertilization 2010 H Hamlin - Fertilization 1. Chemical...

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Fertilization 1. Chemical signaling 2. Sperm transport 3. Capacitation 4. Acrosome reaction and polyspermy
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Sperm guidance: non-mammal • Sperm Attraction - External – 1. Egg attracts sperm by chemotaxis – 2. Common in marine organisms • not well studied in mammals • chemotaxis is species specific Ward G E, Brokaw C J, Garbers D L, Vacquier V D. Chemotaxis of Arbacia punctulata spermatozoa to resact, a peptide from the egg jelly layer. J. Cell Biol. 1985; 101: 2324–2329. [ PubMed ]
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Sperm Anatomy Sperm has – head – mid piece – tail 3 key components – nucleus – propulsion system – sac of enzymes to penetrate egg
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Sperm Morphology • Vary in shape • Heads contain – Condensed DNA – Acrosome • Highly modified lysosome – Proteins Mouse Opossum
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Sperm sensitivity to chemo-attractant • Femtomolar concentrations • 14,000 - 1,000,000 receptors per sperm • “works” up to micromolar concentrations • Highly species specific
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Brainless movement: mechanisms of chemotaxis in urchins Kaupp et al., 2007; Annu. Rev. Physiol.
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Sperm swimming patterns Kaupp et al., 2007; Annu. Rev. Physiol.
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Sperm guidance in mammals • “Competitive race” model • Chemotaxis and thermotaxis
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This note was uploaded on 05/19/2011 for the course ZOO 4926 taught by Professor Staff during the Summer '08 term at University of Florida.

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15. Fertilization 2010 H Hamlin - Fertilization 1. Chemical...

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