Seifert lecture - Vertebrate Anogenital Development Ashley...

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Vertebrate Anogenital Development Ashley W. Seifert Department of Biology
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Murine External Genital Development
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Penis of the deer mouse, Peromyscus maniculatus from Hooper. 1958. Mus. Zool. Univ. Mich. Misc. Publ. 105.
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E9.5 E10.5 E8.5 E7.5
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E10.5: germ cells are arriving at the genital ridges and begin to invade the gonad
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External Genital Development Begins
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Male Female
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Modified from: Perriton (2003) Dissertation Male Female urethra urethra prepuce glans
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Ectoderm preputial glands, skin Mesoderm erectile tissue, connective tissue, smooth muscle, cartliage, bone Endoderm urethra
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E9.5 E10.75 E11.5 E12.0 E12.5 E13.5
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Seifert et al. 2008 Dev. Biol Mouse E10.5 E11.0 E12.5 E13.5 tail tail tail cloacal membrane hindgut urogenital sinus genital tubercle
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Sexual Differentiation E15.5 E14.5 Male Female Seifert et al. 2008 Dev. Biol Modified from: Perriton (2003) Dissertation Hormonal Regulation
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Male Female
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Seifert et al. 2008 Dev. Biol Androgen signaling drives masculinization
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This note was uploaded on 05/19/2011 for the course ZOO 4926 taught by Professor Staff during the Summer '08 term at University of Florida.

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Seifert lecture - Vertebrate Anogenital Development Ashley...

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