LECTURE-4 - Aging and Aging and Life Life-prolonging...

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Unformatted text preview: Aging and Aging and Life Life-prolonging interventions prolonging interventions Lecture 4 Lecture 4 *slide contributions by Drs C. Leeuwenburgh *slide contributions by Drs C. Leeuwenburgh T. T. Prolla Prolla and R. Weindruch and R. Weindruch Aging and Aging and Caloric restriction Caloric restriction Reduction in Caloric Intake without Reduction in Caloric Intake without malnutrition malnutrition Characteristics Characteristics Increases mean and maximum life span Increases mean and maximum life span Sixty years ago scientist at Cornell University made the Sixty years ago scientist at Cornell University made the extraordinary discovery extraordinary discovery -McCay McCay Reduces tumors, renal disease, Reduces tumors, renal disease, cardiomyopathy cardiomyopathy CR is effective starting at mid-age NIH-31/NIA Fortified Diet (CR)NIH31 Average Nutrient Composition (AL) Average Nutrient Composition NIH-31/NIA Fortified NIH-31 Protein % 18.74 18.42 Fat % 4.41 4.47 Fiber % 4.58 4.05 Ash % 6.51 6.64 Nitrogen-Free Extract % 55.04 55.91 Gross Energy kcal/g 3.95 4.02 Digestible Energy kcal.g 3.36 - Metabolizable Energy kcal.g 3.07 - Linoleic Acid % 1.79 - Moisture % - 10.51 Amino Acids NIH-31/NIA Fortified NIH-31 Arginine % 1.10 1.06 Methionine % 0.36 0.39 Histidine % 0.42 0.41 Leucine % 1.50 1.61 Lysine % 0.96 0.95 Tryptophan % 0.22 0.24 Valine % 0.88 0.96 Cystine % 0.26 0.28 Isoleucine % 0.76 0.90 Threonine % 0.71 0.71 Pherylalanine % 1.53 Pherylalanine 0.92 +Tyrosine Tyrosine 0.70 Minerals NIH-31/NIA Fortified NIH-31 Calcium % 1.03 1.06 Phosphorus % 0.93 0.92 Sodium % 0.30 0.26 Chlorine % 0.48 0.42 Potassium % 0.59 0.59 Magnesium % 0.20 0.20 Iron mg/Kg 336.41 300.20 Maganese mg/Kg 156.01 152.80 Zinc mg/Kg 48.41 50.40 Copper mg/Kg 13.28 13.20 Iodine mg/Kg 2.01 1.94 Cobalt mg/Kg 0.53 0.53 Selenium mg/Kg 0.30 - Vitamins NIH-31/NIA Fortified NIH-31 Vitamin A IU/g 40.49 - Vitamin A3 IU/g - 30.73 Vitamin D3 IU/g 7.00 4.19 Vitamin E mg/Kg 52.15 38.30 Choline mg/g 2.60 1.96 Niacin mg/Kg 116.16 92.20 Pantothenic Acid mg/Kg 55.07 39.50 Pyridoxine mg/Kg 13.16 10.20 Riboflavin mg/Kg 11.04 7.80 Thiamine mg/Kg 123.44 77.30 Menadione mg/Kg 111.01 22.00 Folic Acid mg/Kg 2.13 1.70 Biotin mg/Kg 0.38 0.13 Vitamin B12 mcg/Kg 93.80 53.00 Vitamin C mg/g - - Carotene mg/Kg - - Caloric Restriction Increases Both Average and Maximal Life Span In Experimental Animals White Rat On a normal diet, average life span is 23 months with a max of 33 months When intake is restricted (by about 1/3), average life span is 33 months and maximal life span is 47 months Adapted from Hursting et al, Annual Reviews of Medicine, 54:131-152,2003. Continue Relationship has also been demonstrated with: spiders, insects, fish, and even protozoa....
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LECTURE-4 - Aging and Aging and Life Life-prolonging...

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