LECTURE-9 - Low Density Lipoprotein Oxidation Theory as a...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Low Density Lipoprotein Oxidation Theory as a cause to Atherosclerosis Dr. Christiaan Leeuwenburgh Outline: Atherosclerosis LDL oxidation hypothesis Antioxidant Intervention Exercise/Diet Stages of Arteriosclerosis Starts at a young age (10-14) Fatty Streaks = white-gray areas protrude into the lumen Intermediate lesions = macrophage infiltration Advanced lesion = fibrous plaques (connective tissues, smooth muscle cells, accumulated lipids and lipid laden macrophages -foam cells) Atherosclerosis Hardening of the Arteries 50% of deaths in the US, Europe, and Japan Plaques or atheromas protrude into lumen and reduce blood flow to organs Serve as sites for thrombus formation (blood clots) Begins as a result of damage to endothelium The gross appearance of severe coronary atherosclerosis, which involves virtually 100% of the surface of the coronary. There is extensive calcification, especially at the right where the lumen is narrowed. Factors that promote CVD Smoking (lowers antioxidant defenses -free radicals) High blood Cholesterol/LDL (LDL-particle LDL-ox) High Blood Pressure Diabetes (glucose) Lack of Exercise (These processes may all interfere with normal healthy maintenance of the endothelial lining) Risk Factors Lack of Exercise High Fat Diet: Fast-food meal contains 40-58% of the calories as fats - RDA < 30% Smokers Heredity Stress African American Women Normal human coronary artery with no...
View Full Document

This note was uploaded on 05/19/2011 for the course BCH 3218 taught by Professor Johnsteward during the Fall '08 term at University of Florida.

Page1 / 6

LECTURE-9 - Low Density Lipoprotein Oxidation Theory as a...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online