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Unformatted text preview: Low Density Lipoprotein Oxidation Theory as a cause to Atherosclerosis Dr. Christiaan Leeuwenburgh Outline: Atherosclerosis LDL oxidation hypothesis Antioxidant Intervention Exercise/Diet Stages of Arteriosclerosis Starts at a young age (10-14) Fatty Streaks = white-gray areas protrude into the lumen Intermediate lesions = macrophage infiltration Advanced lesion = fibrous plaques (connective tissues, smooth muscle cells, accumulated lipids and lipid laden macrophages -foam cells) Atherosclerosis Hardening of the Arteries 50% of deaths in the US, Europe, and Japan Plaques or atheromas protrude into lumen and reduce blood flow to organs Serve as sites for thrombus formation (blood clots) Begins as a result of damage to endothelium The gross appearance of severe coronary atherosclerosis, which involves virtually 100% of the surface of the coronary. There is extensive calcification, especially at the right where the lumen is narrowed. Factors that promote CVD Smoking (lowers antioxidant defenses -free radicals) High blood Cholesterol/LDL (LDL-particle LDL-ox) High Blood Pressure Diabetes (glucose) Lack of Exercise (These processes may all interfere with normal healthy maintenance of the endothelial lining) Risk Factors Lack of Exercise High Fat Diet: Fast-food meal contains 40-58% of the calories as fats - RDA < 30% Smokers Heredity Stress African American Women Normal human coronary artery with no...
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This note was uploaded on 05/19/2011 for the course BCH 3218 taught by Professor Johnsteward during the Fall '08 term at University of Florida.
- Fall '08