Week 4 notes 2 - T reatment of Diarrhea As with other GI...

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Treatment of Diarrhea As with other GI symptoms, it is important to identify and treat the underlying condition whenever possible. Control of acute diarrhea can usually be achieved with opiates or adsorbant drugs. List of Available Opiate Antidiarrheal Drugs diphenoxylate (Lomotil) loperamide (Imodium) Pharmacodynamics of the Opiate Antidiarrheal Drugs As opiate drugs, these agents interact with and block mu opiate receptors on the smooth muscle cells of the intestinal wall. By blocking these receptors, contraction of the smooth muscle cells is decreased and peristalsis is decreased. Transit through the intestinal tract is, therefore, slowed and the frequency of stools is decreased. Loperamide (Imodium) only interacts with the intestinal smooth muscle cells and has no action on the mu receptors in the central nervous system. Therefore, it cannot be used as an analgesic. Diphenoxylate (Lomotil), on the other hand, can interact with mu receptors in the brain and can satisfy the craving of an opiate "addict". To ensure that it is not used in this way the pharmaceutical company combines diphenoxylate with atropine in the product Lomotil. Lomotil, therefore, will
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This note was uploaded on 05/19/2011 for the course NURSING 517/617 taught by Professor Lipstate during the Spring '11 term at University of Louisiana at Lafayette.

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Week 4 notes 2 - T reatment of Diarrhea As with other GI...

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