Week 4 notes 8 - TreatmentofRespiratoryMucus Mucolytics are...

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Treatment of Respiratory Mucus Mucolytics are used to enhance the clearance of airway secretions in conditions such as chronic bronchitis and cystic fibrosis. Drugs (Mucolytics) Used for Respiratory Mucus N-acetylcysteine (Mucomyst) (Mucosil) dornase alfa (Pulmozyme) (DNase) Pharmacodynamics of N-acetylcysteine N-acetylcysteine interacts with and breaks disulfide chemical bonds that hold the component glycoprotein molecules of mucus together. In doing so, the glycoprotein molecules come apart and this allows water molecules to enter and "liquify" the mucus, making it easier for the respiratory cilia to clear it from the airway and move it into the throat for expectoration. This also makes the cough effort easier for debilitated patients. Pharmacokinetics of N-acetylcysteine For respiratory indications, N-acetylcysteine is administered as an inhalant. As an inhalant, very little of the drug is absorbed systemically. Any that is absorbed is metabolized by the liver and excreted in the urine. Advantages of N-acetylcysteine for Respiratory Mucus
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This note was uploaded on 05/19/2011 for the course NURSING 517/617 taught by Professor Lipstate during the Spring '11 term at University of Louisiana at Lafayette.

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Week 4 notes 8 - TreatmentofRespiratoryMucus Mucolytics are...

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