cell death (1) - Apri l 7, 2011 Cell Death First the cell...

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April 7, 2011 Cell Death First the cell looks normal then the cell starts to change and you can see it’s undergoing destruction Apoptosis – there’s blepping (process in which there are changes in the cell membrane where there’s loss of integrity in cell membrane)…cell also undergoes shrinking, nuclear fragmentation, chromatin condensation, and chromosomal fragmentation Between 50 billion to 70 billion cells die every day due to apoptosis – adult o For average adult human in the course of a year, this amount equals the individual’s body weight For an average child (8-14), 20-30 billion cells die per day Plays a major role in preventing cancer (read about tumor suppressing p53 gene) Calcium and magnesium – play a role in DNA fragmentation Decrease in cell volume (due to shrinkage of cytoplasm) Loss of mitochondrial function Membrane blepping In terms of embryological development, apoptosis helps tissues differentiate **Control of digit webbing in newborns also has to do with proteins
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cell death (1) - Apri l 7, 2011 Cell Death First the cell...

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