Inhibitors - Computational Molecular Biology Pooling...

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Computational Molecular Biology Pooling Designs – Inhibitor Models
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My T. Thai [email protected] 2 An Inhibitor Model In sample spaces, exists some inhibitors Inhibitor = anti-positive (Positives + Inhibitor) = Negative _ + _ _ _ _ _ x Inhibitor Negative +
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My T. Thai [email protected] 3 An Example of Inhibitors
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My T. Thai [email protected] 4 Inhibitor Model Definition: Given a sample with d positive clones, subject to at most r inhibitors Find a pooling design with a minimum number of tests to identify all the positive clones (also design a decoding algorithm with your pooling design)
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My T. Thai [email protected] 5 Inhibitors with Fault Tolerance Model Definition: Given n clones with at most d positive clones and at most r inhibitors , subject to at most e testing errors Identify all positive items with less number of tests
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My T. Thai [email protected] 6 Preliminaries
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My T. Thai [email protected] 7 2-stages Algorithm What is AI? The set AI should contains all the inhibitors and no positives . Hence the set PN contains all positives (and some negatives) but no inhibitors
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My T. Thai [email protected] 8 2-stages Algorithm At this stage, the problem become the e-error- correcting problem.
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My T. Thai
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