apixaban.pdf - Name\/bks_53161_deglins_md_disk\/apixaban 01:33PM 1 REMS apixaban(a-pix-a-ban Eliquis Classification Therapeutic anticoagulants

apixaban.pdf - Name/bks_53161_deglins_md_disk/apixaban...

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Canadian drug name. Genetic Implication. CAPITALS indicate life-threatening, underlines indicate most frequent. Strikethrough Discontinued. 1 REMS apixaban (a- pix -a-ban) Eliquis Classification Therapeutic: anticoagulants Pharmacologic: factorXainhibitors Pregnancy Category B Indications Decreases risk of stroke/systemic embolism associated with nonvalvular atrial fibril- lation. Action Acts as a selective, reversible site inhibitor of factor Xa, inhibiting both free and bound factor. Does not affect platelet aggregation directly, butdoesinhibit thrombin- induced platelet aggregation. Decreases thrombin generation and thrombus devel- opment. TherapeuticEffects: Decreased thromboticeventsassociatedwithatrial fibrillation including stroke and systemicembolization. Pharmacokinetics Absorption: 50%absorbed followingoraladministration. Distribution: Unknown. Metabolism and Excretion: 25% metabolized (mostly by CYP3A4) and ex- creted in urine and feces. Biliary and direct intestinal excretion account for fecal elimination. Half-life: 6 hr (12 hrafter repeated dosing dueto prolongedabsorption). TIME/ACTIONPROFILE (effect on hemostasis) ROUTE ONSET PEAK DURATION PO unknown 3–4hr† 24 hr †Blood levels. Contraindications/Precautions Contraindicated in: Previous severe hypersensitivity reactions; Active pathologi- cal bleeding; Severe hepatic impairment; Not recommended for use in patients with prosthetic heart valves; Concurrent use of strong dual inducers of CYP3A4 and P-gp; Lactation: Shouldnot be used.
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  • Spring '20
  • Atrial fibrillation, Apixaban

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