budesonide.pdf -...

This preview shows page 1 - 2 out of 3 pages.

Canadian drug name. Genetic Implication. CAPITALS indicate life-threatening, underlines indicate most frequent. Strikethrough Discontinued. 1 budesonide (byoo- des -oh-nide) PulmicortRespules,PulmicortFlexhaler Classification Therapeutic: anti-inflammatories(steroidal) Pharmacologic: corticosteroids Pregnancy Category B Indications Nebulization— Maintenance treatment and prophylactic therapy of asthma. Oral inhalation— Chronic control of persistent bronchial asthma. May decrease re- quirement for or eliminate use of systemic corticosteroids over time in patients with asthma. Action Potent, locally acting anti-inflammatory and immune modifier. Therapeutic Ef- fects: Decreases frequency/severity ofasthmaattacks.Improves asthmasymptoms. Pharmacokinetics Absorption: Flexhaler— 39%; Respules— 6%. Action is primarily local follow- ing inhalation. Distribution: Crosses placenta;enters breastmilkin smallamounts. ProteinBinding: 85–90%. MetabolismandExcretion: Metabolized by the liver(primarilybyCYP3A4)fol- lowing absorption from lungs;60%excreted in urine,40%in feces. Half-life: Adults— 2–3.6hr; Children 10–14 yrs— 1.5hr; Children 4–6 yrs— 2.3 hr (after nebulization). TIME/ACTIONPROFILE (improvementin symptoms) ROUTE ONSET PEAK DURATION Inhaln within 24 hr 1–4 wk† unknown Nebulization with2–8 days 4–6 wk unknown †Improvement in pulmonaryfunction; decreased airwayresponsivenessmaytakelonger Contraindications/Precautions Contraindicated in: Hypersensitivity to budesonide; Acute attack of asthma/ status asthmaticus. Use Cautiously in: Active untreated infections; Diabetes or glaucoma; Underlying immunosuppression (from disease or concurrent therapy); Systemic corticosteroid therapy (should not be abruptly discontinued when inhaled therapy is started; addi- tional corticosteroids needed during stress or trauma); OB: Has been used safely; use only if clearly needed; Lactation: Effects on infant are not known; Pedi: Higher than recommended doses can lead to suppression of hypothalamic-pituitary-adrenal (HPA) function and suppression oflineargrowth.

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture