Drug interactions - Interactions * Drugs which may cause...

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Interactions ** Drugs which may cause seizures ** Antipsychotics Ciprofloxacin Desvenlafaxine Duloxetine Donepezil MAOIs Mianserin Mirtazapine Norfloxacin Promethazine (Phenergan) Reboxetine SSRI TCA Trimeprazine (Vallergan) Venlafaxine ** Drugs with anticholinergic effects ** Amitriptyline Benztropine Chlorpheniramin Chlorpromazine (Largactil) Chlomipramine (Anafranil/Placil) Dothiep Doxepin Diphenhydramine Dexchlorpheniramine (Polaramine) Hyoscine Ipratropium
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Imipramine Mianserin (Tolvon/Lumin) Nortriptyline Olanzapine Pheniramine (Avil) Solifenacin Tiotropium Trimeprazine (Vallergan) ** Drugs that may cause folic acid deficiency ** Antiepileptics (barbiturates, carbamazepine, phenytoin) Methotrexate, triamterene, trimethoprim Sulfasalazine ** Drugs which may prolong QT interval ** Amiodarone, sotalol Droperidol, haloperidol Clarithromycin, erythromycin, fluconazole, mefloquine, quinine TCA, vardenafil ** Drugs that cause photosensitivity ** Amiodarone, griseofulvin, NSAIDS, quinolones, retinoids, SJW, tetracyclines, thaizides ** Drugs that affects blood glucose concentration ** Increase Decrease Beta 2 agonists Chlorpromazine CS (not fludrocortisone) Alcohol Aspirin (analgesic dose) Quinine
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Haloperidol Nicotinic acid Olanzapine Paliperidone, phenytoin Quetiapine Risperidone TCAs, thiazide diuretics (high dose) Trimethoprim with sulfamethoxazole ** Drugs that may contribute to serotonin toxicity ** Desvenlafaxine, duloxetine, SJW, MAOIs, TCAs, SSRI, venlafaxine Dextromethorphan, fentanyl, pethidine Phentermine, sibutramine Lithium CARDIOVASCULAR + Lithium + Loop diuretics – increased risk of hypotension, renal impairment + NSAIDS – may increase BP and risk of renal impairment and hyperkalaemia + Thiazide diuretics – First dose hypotension Spironolactone (Aldactone) + NSAID – increased risk of hyperkalaemia + Digoxin Amiloride (Natrilix) + NSAIDS – increased risk of hyperkalaemia Amiodarone (Codarone X) Has a very long half life so interaction may prolong after stopping Inhibits CYP2C9 and CYP2D6 ** potential to cause pro-arrythmic effects ** + drugs that cause QT prolongation + cholestyramine + digoxin + metoprolol + phenytoin + simvastatin + warfarin Beta blockers + verapamil + can cause hypotension + B2 agonists + NSAIDS (can cause hypertension hence impair effectiveness)
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Metoprolol (Betaloc) + amiodarone (may increase metoprolol’s conc) + cimetidine (“) + lercanidipine Propranolol (Inderal) + chlorpramzine +cimetidine Sotalol (Solavert) + QT interval + electrolyte abnormalities Calcium channel blockers + drugs that can cause hypotension Diltiazem (Vasocardol) is metabolised and can inhibit CYP3A4 + atorvastatin, simvastatin + buspirone + carbamazepine, cimetidine, colchicine + digoxin, ivabradine + midazolam, phenytoin Felodipine (Felodur, Plendil) + erythromycin (may increase conc) + itraconazole (may increase conc) Lercanidipine (Zanidip)+ ketoconazole
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This note was uploaded on 05/19/2011 for the course PHAR 3011 taught by Professor Don'tknow during the Three '07 term at University of Sydney.

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Drug interactions - Interactions * Drugs which may cause...

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