LeadingLaggingLec1415.pptx

LeadingLaggingLec1415.pptx - This PowerPoint presentation...

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Unformatted text preview: This PowerPoint presentation deals with DNA replication in prokaryotes as DNA is synthesized away from OriC in both directions. Prokaryotic DNA Replication First of all, you have to think bidirectionally. Prokaryotic DNA Replication First of all, you have to think bidirectionally. Starting at OriC, a new strand of DNA is synthesized along each original strand of DNA in both directions, clockwise and counterclockwise, as the two replication forks move away from OriC in each direction. Prokaryotic DNA Replication First of all, you have to think bidirectionally. Starting at OriC, a new strand of DNA is synthesized along each original strand of DNA in both directions, clockwise and counterclockwise, as the two replication forks move away from OriC in each direction. Along each original strand, in one direction synthesis is discontinuous that is a lagging strand, while in the other direction, synthesis is continuous and that is a leading strand. Prokaryotic DNA Replication A primer for the leading strand is synthesized at OriC and DNA polymerase III synthesizes the leading strand away from OriC as that replication fork moves away from OriC. As the other replication fork moves away from OriC in the opposite direction, that same new strand is being synthesized as a lagging strand, so the Frst primer is put down a little way away from OriC and the Frst Okazaki fragment is synthesized by DNA polymerase III back to OriC where it meets up with the primer that was put down for the strand being made continuously away from OriC. Prokaryotic DNA Replication So, the leading strand primer is removed early in the game by DNA polymerase I when the frst Okazaki Fragment From the other direction meets up with it, then the ends are ligated together....
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LeadingLaggingLec1415.pptx - This PowerPoint presentation...

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