Medical Genetics and Cancer.ppt

Medical Genetics and Cancer.ppt - BIO 325 Genetics Lectures...

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Unformatted text preview: BIO 325 Genetics Lectures 36 and 37 Medical Genetics and Cancer Would that life were like the shadow cast by a wall or tree, but it is like the shadow of a bird in flight. Talmud Human traits are determined both by genetics and the environment. Genetic Analysis of Human Diseases Human traits are determined both by genetics and the environment. The following suggest a genetic basis for a disease: Genetic Analysis of Human Diseases Human traits are determined both by genetics and the environment. The following suggest a genetic basis for a disease: When an individual exhibits a disease, this disorder is more likely to occur in genetic relatives than in the general population. Genetic Analysis of Human Diseases Human traits are determined both by genetics and the environment. The following suggest a genetic basis for a disease: When an individual exhibits a disease, this disorder is more likely to occur in genetic relatives than in the general population. Identical twins (monozygotic twins) share the disease more often than non-identical (dizygotic) twins. Genetic Analysis of Human Diseases Concordance is the degree to which a disease is inherited. It is figured by calculating the percentage of twin pairs in which both twins exhibit the disorder relative to pairs where only one twin has the disorder. Genetic Analysis of Human Diseases Concordance is the degree to which a disease is inherited. It is figured by calculating the percentage of twin pairs in which both twins exhibit the disorder relative to pairs where only one twin has the disorder. Diseases caused by a single gene should have 100% concordance in identical twins. Genetic Analysis of Human Diseases Concordance is the degree to which a disease is inherited. It is figured by calculating the percentage of twin pairs in which both twins exhibit the disorder relative to pairs where only one twin has the disorder. Diseases caused by a single gene should have 100% concordance in identical twins. For dizygotic twins, concordance of dominant disorders is expected to be 50%. Genetic Analysis of Human Diseases Heterozygous x Homozygous Recessive Parent 1 - Aa Parent 2 - aa Parent 1s Sex Cells A a Parent 2s Sex Cells a 50% Aa 50% aa (affected) (normal) 50% Dom. 50% Rec. Autosomal Dominant Disorder Concordance is the degree to which a disease is inherited. It is figured by calculating the percentage of twin pairs in which both twins exhibit the disorder relative to pairs where only one twin has the disorder. Diseases caused by a single gene should have 100% concordance in identical twins. For dizygotic twins, concordance of dominant disorders is expected to be 50%. For recessive diseases, the concordance among dizygotic twins would be 25%....
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This note was uploaded on 05/19/2011 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

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Medical Genetics and Cancer.ppt - BIO 325 Genetics Lectures...

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