Chapter11&12R

Chapter11&12R - Chapter 11 & 12 Review, page 1...

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Unformatted text preview: Chapter 11 & 12 Review, page 1 BCH 4054 Chapter 11 & 12 Review Lecture Notes Slide 1 Nucleic Acid Structure Linear polymer of nucleotides Phosphodiester linkage between 3 and 5 positions See Figure 11.17 Slide 2 Nucleic Acid Sequence Abbreviations Sequence normally written in 5-3 direction, for example: N N N N H2N O H O H H H H P O O- O H N N N O NH2 N O H H H H H O P O O- O N H2N O N O H O H H H H P O O- O H N O O N O H O H H H H P O O- O O Adenine Guanine Cytosine Thymine Slide 3 Sequence Abbreviations, cont. Let Let er stand for base: A G C T P P P P P 5'-end 3'end Let Letter stand for nucleoside pApGpCpTp 5'-end 3'-end Let Letter stand for nucleotide AGCT 5'-end 3'-end Chapter 11 & 12 Review, page 2 Slide 4 Biological Roles of Nucleic Acids DNA carries genetic information 1 copy (haploid) or 2 copies (diploid) per cell See History of Search for Genetic Material (under external links). RNA at least four types and functions messenger RNAstructural gene information transfer RNAtranslation dictionary ribosomal RNAtranslation factory small nuclear RNARNA processing Slide 5 DNA Structure Watson-Crick Double Helix Clues from Chargaffs Rules A=T, C=G, purines=pyrimidines Helical dimensions from Franklin and Wilkins X-ray diffraction studies Recognition of complementary base pairing possibility given correct tautomeric structure (See Figs. 11.6, 11.7, 11.20) Slide 6 Nature of DNA Helix Antiparallel strands Ribose phosphate chain on outside Bases stacked in middle like stairs in a spiral staircase Figure 11.19schematic representation Complementary strands provide possible mechanism for replication Figure 11.21 representation of replication process Chapter 11 & 12 Review, page 3 Slide 7 Size of DNA Molecules 2 nm diameter, about 0.35 nm per base pair in length Very long, millions of base pairs Organism Base Pairs MW Length SV 40 virus 5.1 Kb 3.4x10 6 1.7 m phage 48 Kb 32 x 10 6 17 m E. coli 4,600 Kb 2.7 x 10 9 1.6 mm Yeast 13,500 Kb 9 x 10 9 4.6 mm Human 2.9 x 10 6 Kb 1.9 x 10 12 0.99 m Slide 8 Packaging of DNA...
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This note was uploaded on 05/22/2011 for the course BCH 4054 taught by Professor Logan/gilmer during the Spring '06 term at FSU.

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Chapter11&12R - Chapter 11 & 12 Review, page 1...

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