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Chapter20 - BCH 4054 Chapter 20 Lecture Notes Slide 1...

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Chapter 20, page 1 BCH 4054 Chapter 20 Lecture Notes Slide 1 Chapter 20 The Tricarboxylic Acid Cycle Slide 2 TCA Cycle aka Krebs Cycle and Citric Acid Cycle Occurs inside mitochondria (the matrix) Overall reaction: Acetyl-CoA + 3 NAD + + CoQ + GDP + P i 2 CO 2 + 3 NADH + CoQH 2 + GTP + CoASH Bridging reaction required that converts pyruvate to acetyl-CoA. Mitochondria have two membranes: inner and outer. The outer has pores and is permeable to many things. The inner is a permeability barrier which requires specific transporters for most compounds to move across it. The matrix is inside the inner membrane. Slide 3 Bridging Reaction: Pyruvate Acetyl-CoA Catalyzed by Pyruvate Dehydrogenase Overall reaction: Pyruvate + CoASH + NAD + Acetyl-CoA + NADH + CO 2 • Two cosubstrate coenzymes: Coenzyme A and NAD + • Three prosthetic group coenzymes: thiamine pyrophosphate, lipoic acid, FAD The reaction is an oxidative decarboxylation of an alpha keto acid.
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