Chapter 20, page 1 BCH 4054 Chapter 20 Lecture Notes Slide 1 Chapter 20The Tricarboxylic Acid CycleSlide 2 TCA Cycleaka Krebs Cycleand Citric Acid Cycle•Occurs inside mitochondria (the matrix)•Overall reaction:Acetyl-CoA + 3 NAD++ CoQ + GDP + Pi↓2 CO2+ 3 NADH + CoQH2+ GTP + CoASH•Bridging reaction required that converts pyruvate to acetyl-CoA.Mitochondria have two membranes: inner and outer. The outer has pores and is permeable to many things. The inner is a permeability barrier which requires specific transporters for most compounds to move across it. The matrix is inside the inner membrane. Slide 3 Bridging Reaction: Pyruvate →Acetyl-CoA•Catalyzed by Pyruvate Dehydrogenase•Overall reaction:Pyruvate + CoASH + NAD+→Acetyl-CoA + NADH + CO2• Two cosubstratecoenzymes:•Coenzyme A and NAD+• Three prosthetic groupcoenzymes:•thiamine pyrophosphate, lipoic acid, FADThe reaction is an oxidative decarboxylation of an alpha keto acid.
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