Chapter 31, page 1 BCH 4054 Chapter 31 Lecture Notes Slide 1 Chapter 31Transcription andRegulation of Gene ExpressionSlide 2 Messenger RNA•Central Dogma (Francis Crick, 1958)• DNA →RNA →Protein (Fig 31.1)•Jacob-Monod Hypothesis: Four properties•Base composition reflecting DNA•Heterogeneous in size•Can associate with ribosomes•High rate of turnoverEarly labeling experiments showed ribosomes as the site of protein synthesis. An alternate hypothesis was that each protein had its own specific ribosome where it is made. Slide 3 Other Forms of RNA•Ribosomal RNA•Major RNA component of cell•Transfer RNA•Small RNA molecules carrying the amino acids in protein synthesis•Eukaryotic “small nuclear” RNA•mRNA processing in eukaryotes•Viral RNAAll forms are made by copying a DNA template (excepting some RNA viruses), so the process of transcription is common to all.
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