test4 - BCH 4054 HOUR TEST 4 NAME Page(6 1 Using partial...

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BCH 4054 November 19, 1999 HOUR TEST 4 NAME_____________________ (6) 1. Using partial structures to designate the tetrahydrofolic acid (i.e., showing just the N 5 and N 10 positions of the molecule), give the structure of the following C 1 -derivatives of THF: (a) The product formed from serine. (b) The precursor of the 2 position of purines. (c) The C 1 donor in thymidylate biosynthesis. Page Points 1 ____ 2 ____ 3 ____ 4 ____ Total ______ (a) (b) (c) (6) 2. Following are two structures, of a purine. (a) Give the name of the purine. (b) In the first structure circle each nitrogen atom that is derived from glutamine , and put an X through each nitrogen atom that is derived from aspartate . (c) In the second structure circle each carbon atom that is derived from CO 2 , and put an X through each carbon atom that is derived from N 10 -formyl THFA . N HN N H N O H 2 N N HN N H N O H 2 N Name ________________ (4) 3. What enzyme is inhibited by the drugs aminopterin and amethopterin , and why are these drugs effective in blocking the growth of cancer cells? (6) 4. What enzyme is deficient in Lesh-Nyhan syndrome, what product accumulates, and how does deficiency of this enzyme cause the accumulation of this product?
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BCH 4054 --Hour Test 4 Page 2 Name________________________ (5) 5. Ribose is first activated before incorporation into either purine or pyrimidine nucleotides. Draw the structure of this activated form of ribose.
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This note was uploaded on 05/22/2011 for the course BCH 4054 taught by Professor Logan/gilmer during the Spring '06 term at FSU.

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test4 - BCH 4054 HOUR TEST 4 NAME Page(6 1 Using partial...

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