chapter10 - BCH 4053 Summer 2001 Chapter 10 Lecture Notes...

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Chapter 10, page 1 BCH 4053 Summer 2001 Chapter 10 Lecture Notes Slide 1 Chapter 10 Membrane Transport Slide 2 Thermodynamics of Transport Free Energy change is given by difference in electrochemical potential and the quantity transported 2 1 G = n( ) where = the electrochemical potential m m m - Recall from Chapter 3 = RTlnC + ZF o m m + Ψ where C is the concentration (actually the activity), Z is the charge, F is the Faraday constant (96.5 kJ/volt-mol) and is the electrical potential of the solution Ψ We did not discuss the electrical component in Chapter 3. Recall that what we are calling C here is really the activity, i.e. the concentration relative to the standard state. Review your standard state conventions. Because μ o is the same on both sides of the membrane, this term cancels out. Slide 3 Thermodynamics of Transport, con’t. 2 1 chemical work electrical work Therefore the free energy of transport is given by C G = nRTln nZF C + ∆Ψ See Figures 10.1 and 10.2 Remember if G is negative, the process is spontaneous, and G represents the maximum work we can get from the process. If G is positive, the process is not spontaneous, and G is the minimum work required to realize it. The first term is negative when a substance is moving from a high concentration to a lower concentration (C 2 < C 1 ). The second term is negative when a positive ion (Z is +) moves to a lower potential ( ∆Ψ is -) or a negative ion (Z is -) moves to a higher potential ( ∆Ψ is +).
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Chapter 10, page 2 Slide 4 Topic Outline Passive Diffusion Facilitated Diffusion Active Transport Driven by ATP hydrolysis (ATPase’s)
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