Chapter 14, page 1 BCH 4053 Summer 2001 Chapter 14 Lecture Notes Slide 1 Chapter 14Enzyme KineticsSlide 2 Enzyme Characteristics•Catalytic Power•Rate enhancements as much as 1014•Specificity•Enzymes can distinguish between closely related chemical species•D and L isomers•cisand trans isomers•Diastereomers (glucose and galactose)•Regulation•Ability to activate or inhibit enzymes can control which reactions occur and when.An example of specificity is illustrated by the enzyme fumarasewhich catalyzes addition of water to the double bond of fumaric acidto form L-malic acid. The cisisomer of fumarate, maleic acid, does not work. Neither does D-malic acid, the enantiomer of L-malic acid. Slide 3 Enzyme Terminology• Substrates•Substances whose reaction is being catalyzed• Products•End products of the catalyzed reaction•For reversible reaction, designation depends on point of view.• A + B °P + Q•A, B products, P, Q reactants, or vice versaAn enzyme is a catalyst, and as such does not influence the equilibriumposition of the reaction—only its rate. So one can start with A and B and get P and Q formed, but one can also start with P and Q and get A and B formed.
has intentionally blurred sections.
Sign up to view the full version.