chapter14 - BCH 4053 Summer 2001 Chapter 14 Lecture Notes...

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Chapter 14, page 1 BCH 4053 Summer 2001 Chapter 14 Lecture Notes Slide 1 Chapter 14 Enzyme Kinetics Slide 2 Enzyme Characteristics Catalytic Power Rate enhancements as much as 10 14 Specificity Enzymes can distinguish between closely related chemical species D and L isomers cis and trans isomers Diastereomers (glucose and galactose) Regulation Ability to activate or inhibit enzymes can control which reactions occur and when. An example of specificity is illustrated by the enzyme fumarase which catalyzes addition of water to the double bond of fumaric acid to form L-malic acid . The cis isomer of fumarate, maleic acid, does not work. Neither does D-malic acid, the enantiomer of L-malic acid. Slide 3 Enzyme Terminology • Substrates Substances whose reaction is being catalyzed • Products End products of the catalyzed reaction For reversible reaction, designation depends on point of view. • A + B ° P + Q A, B products, P, Q reactants, or vice versa An enzyme is a catalyst, and as such does not influence the equilibrium position of the reaction—only its rate. So one can start with A and B and get P and Q formed, but one can also start with P and Q and get A and B formed.
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